PRELIMINARY PROGRAMME 2004

DIABETES, molecular heterogeneity, mechanisms and emerging technologies

Preliminary Programme: Theoretical course
Preliminary Programme: Laboratory Course

University of Lund, August 22 - September 03

Sunday, August 22:

13:00 – 17:00: Registration

17:00 – 17:30: Welcome addresses:
Director of the Baltic Summer School: Bengt Saltin
Dean of the Medical Faculty: Jan Nilsson
Representative of the Government: To be determined
Lund University Organizer: Åke Lernmark
Kiel University Organizer: Günter Klöppel

17:30 - 18:30: Honorary lecture by Sir George Alberti

19:00 - 21:00: Get together

Day 1 - Monday 23.08.04
General topic: Epidemiology, diagnostic criteria and classification
08.50-09.00 Introduction - Å. Lernmark, SE
09.00-10.00 Review - History and epidemiology of diabetes - G. Alberti, UK
10.00-11.00 Lecture - Diagnostic criteria and classification I - K. Borch-Johnsen, DK
11.00-11.30 Break
11.30-12.30 Lecture - Epidemiology – type 1 diabetes - A. Green, DK
12.30-14.00 Lunch
14.00-15.00 Review - Epidemiology – type 2 diabetes and obesity - J. Tuomilehto, FI
15.00-15.30 Break
15.30-16.30 Lecture - Diabetes heterogeneity - L. Groop, SE
16.30-17.30 Review - Animal models of diabetes: overview - H. Luthman, SE
17.30 Round table - All speakers

Day 2 - Tuesday 24.08.04
General topic: Beta cell development and stem cells
08.50-09.00 Introduction - O. Madsen, DK
09.00-10.00 Lecture - Islet stem cell and development - H. Semb, SE
10.00-11.00 Lecture - Beta cell differentiation - O. Madsen, DK
11.00-11.30 Break
11.30-12.30 Lecture - Beta cell regeneration - L. Bouwens, B
12.30-14.00 Lunch
14.00-15.00 Lecture - The transplanted beta cell - P. Int`veld, NL
15.00-15.30 Break
15.30-16.30 Lecture - Differentiation of stem cells to beta cells - TBN
16.30-17.30 Lecture - Animal models: long-term effects of islet transplantation
--------------F. Dombrowski, D
17.30-18.00 Lecture - Ethical considerations - S. Andersen, DK
18.00 Round table - All speakers

Day 3 – Wednesday 25.08.04
General topic: Diabetes genetic etiology
08.50-09.00 Introduction - L. Groop, SE
09.00-10.00 Review - Genetics of type 1 diabetes - F. Pociot, DK
10.00-11.00 Lecture - Tracking type 2 diabetes genes - L. Groop, SE
11.00-11.30 Break
11.30-12.30 Lecture - Monogenic diabetes - H. Luthman, SE
12.30-14.00 Lunch
14.00-15.00 Lecture - Candidates genes in type 2 diabetes - O. Pedersen, DK
15.00-15.30 Break
15.30-16.30 Lecture - Mapping obesity genes - P. Frougel, F
16.30-17.30 Lecture - Animal models of diabetes genetics - H. Luthman, SE
17.30-18.00 Lecture - Emerging new technologies - P. Frougel, F
18.00 Round table - All speakers

Day 4 - Thursday 26.08.04
General topic: The beta cell, pro-inflammation and autoimmunity
08.50-09.00 Introduction - Å Lernmark, SE
09.00-10.00 Review - Apoptosis or necrosis - D. Pipeleers, BE
10.00-11.00 Lecture - Pro-inflammatory mediators - D. Eizirik, BE
11.00-11.30 Break
11.30-12.30 Lecture - Cytokine signalling mechanisms - T. Mandrup-Poulsen, DK
12.30-14.00 Lunch
14.00-15.00 Lecture - Beta cell responses - A.E Karlsen, DK
15.00-15.30 Break
15.30-16.30 Lecture - Immune mediated recognition of beta cells - Å. Lernmark, SE
16.30–17.30 Lecture - Macrophages, dendritic cells in beta cell pathophysiology -
------------- C. Cilio, SE
17.30-18.00 Lecture - Animal models of type 1 diabetes - S. Lenzen, D
18.00 Round table - All speakers

Day 5 – Friday 27.08.04
General topic: The beta cell, overstimulation, degeneration
08.50-09.00 Introduction - G. Klöppel, D
09.00-10.00 Review - Insuline release mechanisms - C. Wollheim, CH
10.00-11.00 Lecture - The beta cell in type 2 diabetes - G. Klöppel, D
11.00-11.30 Break
11.30-12.30 Lecture - Peptide hormones and the beta cell - J.J. Holst, DK
12.30-14.00 Lunch
14.00-15.00 Lecture - Twins studies and beta cell function - H. Beck-Nielsen, DK
15.00.15.30 Break
15.30-16.30 Lecture - Insulin resistance - L. Groop, SE
16.30-17.30 Lecture - Animal models of type 2 diabetes - S. Enerbäck, SE
17.30 Round table - All speakers

Day 6 – Saturday 28.08.04
General topic: Beta cell pathophysiology
08.50-09.00 Introduction - G. Weir, USA
09.00-10.00 Lecture - Glucose toxicity and beta cell function - G. Weir, USA
10.00-11.00 Lecture - IAPP, Islet amyloid and diabetes - J. Höppener, NL
11.00-11.30 Break
11.30-12.30 Lecture - Beta-cell function with and without K-ATP channels
----------- - C. Henquin, BE
12.30-14.00 Lunch
14.00-15.00 Lecture - Islet signalling and cAMP mechanisms - E. Degerman, SE
15.00-15.30 Break
15.30-16.30 Lecture - Beta cell GAD and GABA - P. Rorsman, SE
16.30-17.30 Lecture - Islet lipases and lipotoxicity - C. Holm, SE
17.30-18.00 Lecture - Animal models of glucose toxicity - G. Weir, USA
18.00 Round table - All speakers

SUNDAY 29.08.04 FREE

Day 7 – Monday 30.08.04
General topic: Exo-endo axis
08.50-09.00 Introduction - G. Klöppel, DE
09.00-10.00 Review - Pancreas disease overview - I. Ihse, SE
10.00-11.00 Lecture - Pancreas carcinoma - J. Permert, SE
11.00-11.30 Break
11.30-12.30 Lecture - Pancreatitis - G. Klöppel, DE
12.30-14.00 Lunch
14.00-15.00 Lecture - Patophysiology of acute pancreatitis - A. Borgström, SE
15.00-15.30 Break
15.30-16.30 Lecture - Autoimmune pancreatitis - M. Löhr, DE
16.30–17.30 Lecture - Cystic fibrosis-molecular mechanisms - L. Bolund, DK
17.30-18.00 Lecture - Animal models of diabetes and chronic pancreatitis - R. Graf, CH
18.00 Round table - All speakers

Day 8 – Tuesday 31.08.04
General topic: Pathophysiology of diabetes complications
08.50-09.00 Introduction - C-D Agardh, SE
09.00-10.00 Review - Diabetes complications - C-D Agardh, SE
10.00-11.00 Lecture - The diabetic blood vessels - J. Nilsson, SE
11.00-11.30 Break
11.30-12.30 Lecture - The diabetic foot - J. Apelqvist, SE
12.30-14.00 Lunch
14.00-15.00 Lecture - The diabetic eye - E. Agardh, SE
15.00-15.30 Break
15.30-16.30 Lecture - The diabetic kidney - A. Flyvbjerg, DK
16.30-17.30 Lecture - The diabetic nerves - A.J. Boulton, UK
17.30-18.00 Lecture - Animal models of diabetes complications - J. Nilsson, SE
18.00 Round table - All speakers

Day 9 – Wednesday 01.09.04
General topic: Insulin action
08.50-09.00 Introduction - J. Zierath. SE
09.00-10.00 Review - Dissecting insulin action J. Zierath, SE
10.00-11.00 Lecture - Insulin action in diabetes - A. Vaag, DK
11.00-11.30 Break
11.30-12.30 Lecture - Role of skeletal muscle in type 2 diabetes - B.K. Pedersen, DK
12.30-14.00 Lunch
14.00-15.00 Lecture - Insulin signalling I - L. Goodyear, USA
15.00-15.30 Break
15.30-16.30 Lecture - Hepatic insulin resistance - A. Cherrington, USA
16.30-17.30 Lecture - Low birth weight and type 2 diabetes - A. Vaag, DK
17.30-18.00 Lecture - Exercise, AMPK and insulin action - J.F.Wojtaszewski, DK
18.00 Round table - Bengt Saltin and all speakers

Day 10 – Thursday 02.09.04
General topic: Diabetes prediction and prevention
08.50-09.00 Introduction - J. Nerup, DK
09.00-10.00 Lecture - Prediction and prevention of type 2 diabetes
------------- W.C. Knowler, USA
10.00-11.00 Lecture - Prediction and prevention of type 1 diabetes- A. Green, DK
11.00-11.30 Break
11.30-12.30 Lecture - Screening for type 1 diabetes autoimmunity - O. Simell, SF
12.30-14.00 Lunch
14.00-15.00 Lecture - Screening for type 1 diabetes - P. Bingley, UK
15.00-15.30 Break
15.30-16.30 Lecture - Beta cell proteomics in prediction and prevention - J. Nerup, DK
16.30-17.30 Lecture - Animal models - H. Markholst, DK
17.30-18.00 Round table - All speakers

Day 11 – Friday 03.09.04
General topic: Cytokines in immune and metabolic functions - bridges or barriers?
08.50-09.00 Introduction - M. Schwartz, USA
09.00-10.00 Review - Hypothalamic signaling by insulin and leptin: Implications for obesity --------------M. Schwartz, USA
10.00-11.00 Lecture - Pathways linking cytokines and glucose metabolism - TBN
11.00-11.30 Break
11.30-12.30 Lecture - Inflammation and insulin resistance - S. Shoelson, USA
12.30-14.00 Lunch
14.00-15.00 Lecture - Stress and obesity - TBN
15.00-15.30 Break
15.30-16.30 Lecture - Leptin driven autoimmunity - G. Matarese, I
16.30-17.30 Lecture - Animal models - TBN
17.30-18.00 Round table - All speakers

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Baltic Summer School Lab Course 2004

Thursday, September 2, 2004:
Travel to the different locations (Kiel, Copenhagen, Lund)

Thursday, September 2, 15.00-18.00
Introduction to the Laboratories in Kiel, Günter Klöppel
Introduction to the Laboratories in Copenhagen, Ole Madsen
Introduction to the laboratories in Lund/Malmö, Cecilia Holm

September 2 to September 10:
Laboratory projects in Kiel, Copenhagen and Lund, respectively (projects will be defined).

The projects will take place at the Universities of:
Kiel, Germany
Copenhagen, Denmark
Lund, Sweden
Malmö, Sweden

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