Program Baltic Summer School 2008
Basic and clinical aspects of cardiac arrhythmia’s
University of Copenhagen, August 17nd– August 30th
Sunday, August 17th:
| 13:00 - 17:00 | Registration |
| 17:00 - 18:30 | Welcome addresses and honorary lecture - open for public |
| 17:00 - 17:30 | Welcome addresses: |
| Director of the Baltic Summer School: M. Illert, University of Kiel | |
| 17:30 - 18:30 | Honorary lecture by Dr. David Rosenbaum, Cleveland, USA: |
| Electrophysiological heterogeneity in the beating heart | |
| 19:00 - 21:00 | Get together |
18.08.- 22.08.08 (Monday - Friday): daily sessions
25.08.- 29.08.08 (Monday - Friday): daily sessions
Day 1 (18.08.2008) |
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| General topic: Ion channels | |||
| Chair: Søren-Peter Olesen | |||
| 8.50-9.00 | Introduction | ||
| 9.00-9.45 | Lecture | The mysteries of cardiac beat regulation | Franz Hofmann (Munich, G) |
| 9.45-10.30 | Lecture | Cardiac Na channels | H Todt (Vienna, A) |
| Break | |||
| 11.00-11.45 | Lecture | Cardiac KCNQ1 channels and their interaction with other regulatory proteins | Nicole Schmitt (Copenhagen, DK) |
| 11.45-12.30 | Lecture | Ubiquitinylation of cardiac ion channels | Thomas Jespersen (Copenhagen, DK) |
| 12.30-14.30 | Lunch | ||
| 14.30-15.15 | Lecture | RyR2 receptors and cardiac arrhythmia | S. Richard (Montpellier, F) |
| 15.15-16.00 | Lecture | Cardiac electrical remodelling in health and disease | D. Rosenbaum (Cleveland, USA) |
| 16.00-16.30 | Break | ||
| 16.30-17.30 | Round table | All speakers | |
Day 2 (19.08.2008) |
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| General topic: Ion channels | |||
| Chair: Søren-Peter Olesen | |||
| 8.50-9.00 | Introduction | ||
| 9.00-9.45 | Review | Cardiac arrhythmia | Ursula Ravens (Dresden, G) |
| 9.45-10.30 | Lecture | Genetics of atrial fibrillation | Calum A MacRae (Boston, USA) |
| Break | |||
| 11.00-11.45 | Lecture | QT variability as arrhythmia marker | Morten Thomsen (New York, USA) |
| 11.45-12.30 | Lecture | Activation of hERG channels as a potential anti-arrhythmic treatment | Morten Grunnet (Copenhagen, DK) |
| 12.30-14.30 | Lunch | ||
| 14.30-15.15 | Lecture | Ito currents and cardiac arrhythmia | Kirstine Callø (Copenhagen, DK) |
| 15.15-16.00 | Lecture | The role of hypokalemia in cardiac arrhythmogenesis | Oleg Osadchii (Copenhagen, DK) |
| 16.00-16.30 | Break | ||
| 16.30-17.30 | Round table | All speakers | |
Day 3 (20.08.2008) |
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| General topic: Genetic aspects of arrhythmia | |||
| Chair: Jørgen K. Kanters | |||
| 8.50-9.00 | Introduction | ||
| 9.00-9.45 | Review | Primary Electric syndromes – genetic and pathophysiological background | J. K. Kanters (Copenhagen, DK) |
| 9.45-10.30 | Lecture | How do we identify novel genes involved in ion channel disease | M. Christiansen (Copenhagen, DK) |
| Break | |||
| 11.00-11.45 | Lecture | Has the normal QT interval a genetic background | Arne Pfeufer (Munich, DE) |
| 11.45-12.30 | Lecture | Genetics and sudden death | Elijah Behr (London, UK) |
| 12.30-14.30 | Lunch | ||
| 14.30-15.15 | Lecture | Genetic conservation – A novel risk factor in LQTS | C. Jons (Rochester, USA) |
| 15.15-16.00 | Lecture | Are SNPs important in clinical practice | M. Benn (Copenhagen, DK) |
| 16.00-16.30 | Break | ||
| 16.30-17.30 | Round table | All speakers | |
Day 4 (21.08.2008) |
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| General topic: Gap junctions | |||
| Chair: Morten Schak Nielsen | |||
| 8.50-9.00 | Introduction | ||
| 9.00-9.45 | Review | Introduction to gap junctions | Morten S. Nielsen (DK) |
| 9.45-10.30 | Lecture | Regulation of gap junctional coupling | Mario Delmar (USA) |
| Break | |||
| 11.00-11.45 | Lecture | Role of gap junctions in ventricular arrhythmia | Toon van Veen (Utrecht, NL) |
| 11.45-12.30 | Lecture | Role of gap junctions in atrial fibrillation | Ketil Haugan (DK) |
| 12.30-14.30 | Lunch | ||
| 14.30-15.15 | Review | Trafficking of gap junctional channel in health and disease | Thomas Braunstein (DK) |
| 15.15-16.00 | Lecture | Pharmacology of gap junctions | Mario Delmar (USA) |
| 16.00-16.30 | Break | ||
| 16.30-17.30 | Round table | All speakers | |
Day 5 (22.08.2008) |
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| General topic: Myocardial reperfusion injury | |||
| Chair: Jakob Vinten-Johansen – Marek Treiman | |||
| 8.50-9.00 | Introduction | Ischemia – reperfusion injury – challenge and promise (introductory remarks) | M. Treiman (Copenhagen, DK) |
| 9.00-9.45 | Lecture | An opportunity for injury or salvage - overview of reperfusion injury | J. Vinten-Johansen (Atlanta,USA) |
| 9.45-10.30 | Lecture | Mitochondria as the switch between cell apoptosis, necrosis and salvage | F. DiLisa (Padova, I) |
| 10.30 -11.00 | Coffee | ||
| 11.00-11.45 | Lecture | Survival signaling pathways in cardioprotection following ischemia – reperfusion | D. Hausenloy (London, GB) |
| 11.45-12.30 | Lecture | New role for connexin-43 in the context of reperfusion injury | D.Garcia-Dorado (Barcelona, E) |
| 12.30-14.30 | Lunch | ||
| 14.30-15.15 | Lecture | Nitric oxide in the pathophysiology of myocardial ischemia-reperfusion injury | D.J. Lefer (New York, USA) |
| 15.15-16.00 | Lecture | Ischemic conditioning: a new clinical approach to protection against cellular dysfunction and death? | T. Toftegaard Nielsen (Århus, DK) |
| 16.00-16.30 | Coffee | ||
| 16.30-17.30 | Round table | Cardioprotection in myocardial infarction treatment – models, mechanisms, new theoretical and clinical challenges | All speakers |
Day 6 (25.08.2008) |
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| General topic: Cellular signalling in cardiac failure and hypertrophy | |||
| Chair: Jakob Lerche Hansen | |||
| 8.50-9.00 | Introduction | ||
| 9.00-9.45 | Lecture | 7TM receptor signalling in cardiac failure and hypertrophy | Jakob Lerche Hansen (DK) |
| 9.45-10.30 | Lecture | Lessens from cardiac – specific overexpression of mutant AT1 receptors in transgenic mice | Junichi Sadoshima (USA) |
| Break | |||
| 11.00-11.45 | Lecture | Cardiac phenotypes of mice lacking Angiotensin II receptors | Thomas Walther (UK) |
| 11.45-12.30 | Lecture | What do we know about stem cells in the heart? – an introduction to the field | Mikael Schneider (DK) |
| 12.30-14.30 | Lunch | ||
| 14.30-15.15 | Lecture | Cardiac cell turnover – Residing stem cells and the regenerative capacity of cardiac myocytes | Stefan Jovinge (S) |
| 15.15-16.00 | Lecture | Clinical aspects of stem – cell therapy | Jens Kastrup (DK) |
| 16.00-16.30 | Break | ||
| 16.30-17.30 | Round table | All speakers | |
Day 7 (26.08.2008) |
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| General topic: Mathematical modelling of cardiac function | |||
| Chair: Niels–Henrik Holstein–Rathlou | |||
| 8.50-9.00 | Introduction | ||
| 9.00-9.45 | Review | Arrhythmia mechanisms – lessons from mathematical modelling | N–H Holstein–Rathlou (DK) |
| 9.45-10.30 | Lecture | Modeling drug actions | T. Peitersen (DK) |
| Break | |||
| 11.00-11.45 | Lecture | Virtual tissue engineering of the heart | A. Holden (UK) |
| 11.45-12.30 | Lecture | Detection and modeling of T waves in the ECG | C. Graff (DK) |
| 12.30-14.30 | Lunch | ||
| 14.30-15.15 | Lecture | Systems biology in biomedical sciences – I | Thomas S. Jensen (DK) |
| 15.15-16.00 | Lecture | Systems biology in biomedical sciences – II | Thomas S. Jensen (DK) |
| 16.00-16.30 | Break | ||
| 16.30-17.30 | Round table | All speakers | |
Day 8 (27.08.2008) |
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| General topic: Epidemiology of heart disease | |||
| Chair: Christian Torp–Pedersen | |||
| 8.50-9.00 | Introduction | ||
| 9.00-9.45 | Review | The heart disease epidemic | C. Torp–Pedersen (DK) |
| 9.45-10.30 | Lecture | Epidemiology of AMI and its complications | Lars Køber (DK) |
| Break | |||
| 11.00-11.45 | Lecture | Epidemiology of heart failure | John McMurray (Glascow, UK) |
| 11.45-12.30 | Lecture | Diabetes and heart disease | Per Hildebrandt (DK) |
| 12.30-14.30 | Lunch | ||
| 14.30-15.15 | Lecture | Epidemiology of cardiac arrest | Fredrik Folke (DK) |
| 15.15-16.00 | Lecture | Epidemiology of hypertension | Jan Staessen (B) |
| 16.00-16.30 | Break | ||
| 16.30-17.30 | Round table | All speakers | |
Day 9 (28.08.2008) |
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| General topic: Clinical aspects of cardiac arrhythmias – 1 | |||
| Chair: Jesper Hastrup Svendsen | |||
| 8.50-9.00 | Introduction | ||
| 9.00-9.45 | Lecture | Bradyarrhythmia and conventional pacemaker treatment | Jens Cosedis Nielsen (DK) |
| 9.45-10.30 | Lecture | Treatment of ventricular tachyarrhytmia (antiarrythmic drugs and ICD) | Steen Pehrson (DK) |
| Break | |||
| 11.00-11.45 | Lecture | Characteristics of supraventricular tachyarrhythmia (WPW, AVNRT, atrial flutter) | Hastrup Svendsen (DK) |
| 11.45-12.30 | Lecture | Epidemiology of atrial fibrillation | Jens Friberg (DK) |
| 12.30-14.30 | Lunch | ||
| 14.30-15.15 | Lecture | Activation of the atria during sinus rhythm and atrial fibrillation – the value of surface ECG | Pyotr Platonov (SE) |
| 15.15-16.00 | Lecture | Genetic aspects of atrial fibrillation | Lasse Steen Ravn (DK) |
| 16.00-16.30 | Break | ||
| 16.30-17.00 | Lecture | Interventional treatment of atrial fibrillation | Xu Chen (DK) |
| 17.00-17.30 | Lecture | Pharmacological treatment of atrial fibrillation (antiarrhytmic and antitrombotic treatment) | O.D. Pedersen (DK) |
Day 10 (29.08.2008) |
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| General topic: Clinical aspects of cardiac arrhythmias – 2 | ||||
| Chair: Jesper Hastrup Svendsen | ||||
| 8.50-9.00 | Introduction | |||
| 9.00-9.45 | Lecture | Long QT syndrome (congenital and acquired) | Lauri Toivonen (FIN) |
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| 9.45-10.30 | Lecture | Short QT syndrome | Martin Borggrefe (D) |
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| Break | ||||
| 11.00-11.45 | Lecture | Sudden cardiac death | Henning Bundgaard (DK) |
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| 11.45-12.30 | Lecture | Arrhythmogenic Right Ventricular Cardiomyopathy | Alex H. Christensen (DK) |
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| 12.30-14.30 | Lunch | |||
| 14.30-15.15 | Lecture | Brugada syndrome (mechanisms and clinical aspects) | Jacob Tfelt–Hansen (DK) |
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| 15.15-16.00 | Lecture | Familial catecholaminergic polymorphic ventricular tachycardia | Juliane Theilade (DK) |
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| 16.00-16.30 | Break | |||
| 16.30-17.30 | Round table | All speakers | ||