Program Baltic Summer School 2007

Inflammation: A Key to Common Complex Diseases

University of Lund, September 2^nd–September 13^th

 Print Preliminary Programme

Overview

Sunday, September 2^nd

 Registration and opening ceremony

13.00 - 17.00	Registration
17.00 - 18.00	Welcome address
	Introduction by Rikard Holmdahl and Bo Ahrén
18.00 - 18.45	Honorary Lecture
	Regulatory T cells for immune tolerance and homeostasis
	Shimon Sakaguchi, Kyoto
19.00 - 21.00	Get together (only for registered participants)

Monday - Friday, September 3^rd - 7^th

 Daily Lectures
 Day 1: Evolution and ontogeny of the inflammatory response
 Day 2: The inflammatory syndrome in man
 Day 3: Genetic approaches on human inflammatory diseases part 1
 Day 4: Genetic approaches on human inflammatory diseases part 2
 Day 5: Mimicking human diseases using genetic approaches on animals

Saturday, September 8^th

 Social Event, Excursion to Malmö (only for registered participants)

Sunday - Thursday, September 9^th - 13^th

 Daily Lectures
 Day 6: Innate immunity
 Day 7: Adaptive immunity
 Day 8: Inflammatory effector mechanisms
 Day 9: Prediction and monitoring
 Day 10: New preventive and therapeutic treatment strategies and targets

Wednesday, September 12^th

 Social Event, Baltic Summer School Dinner (only for registered participants)

Please note that all lectures are open to the public but during lunch and coffee breaks food will only be served to registered participants.

Registration and opening ceremony

Sunday, September 2^nd
BMC, Sölvegatan19, Lund

Day 1

Evolution and ontogeny of the inflammatory response

Monday, September 3^rd
Lecture hall: Lundasalen, Regionhuset, Baravägen 1, Lund

08.50 - 09.00 Introduction: Gunnar Lindahl, Lund

09.00 - 09.45 Review: Evolution of MHC and NK receptors in response to infectious disease (Peter Parham, Stanford)

09.45 - 10.30 Lecture: Studying the wound inflammatory response in Drosophila embryos (Paul Martin, Bristol)

10.30 - 11.00 Coffee break

11.00 - 11.45 Lecture: Septic and adjuvant arthritis in mice (Andrej Tarkowski, Göteborg)

11.45 - 12.30 Lecture: Selection of innate immune responses in eukaryotes bybacteria (Staffan Normark, Stockholm)

12.30 - 14.30 Lunch combined with poster session

14.30 - 15.15 Lecture: Evolutionary pressure on MHC in primates (Ronald Bontrop, Rijswijk)

15.15 - 15.45 Coffee break

15.45 - 16.45 Round table: Infections or autoimmunity as selective forces on inflammation (All speakers)

Day 2

The inflammatory syndrome in man

Tuesday, September 4^th
Lecture hall: Lundasalen, Regionhuset, Baravägen 1, Lund

08.50 - 09.00 Introduction: Arne Svejgaard, Copenhagen

09.00 - 09.45 Review: Genetics and epidemiology of rheumatoid arthritis (Anne Barton, Manchester)

09.45 - 10.30 Lecture: Lipoprotein autoimmunity - possibilities for treatment of atherosclerosis (Jan Nilsson, Malmö)

10.30 - 11.00 Coffee break

11.00 - 11.45 Lecture: Psoriasis - Its Immunopathogenesis and Polygenic Base (Karin Scharffetter-Kochanek, Ulm)

11.45 - 12.30 Lecture: Asthma, allergy and skin diseases (William Cookson, London)

12.30 - 14.30 Lunch combined with poster session

14.30 - 15.15 Lecture: Inflammatory bowel disease: Archetype for understanding etiopathogenesis of mucosal inflammation (Stefan Schreiber, Kiel)

15.15 - 15.45 Coffee break

15.45 - 16.30 Lecture: Rheumatic diseases (Mark Feldmann, London)

16.30 - 17.30 Round table: The inflammatory syndrome, common pathways and targets (All speakers)

Day 3

Genetic approaches on human inflammatory diseases part 1

Wednesday, September 5^th
Lecture hall: Lundasalen, Regionhuset, Baravägen 1, Lund

08.50 - 09.00 Introduction: Shohreh Issazadeh-Navikas, Lund

09.00 - 09.45 Review: Genes regulating an allergic response - importance in the inflammatory syndrome (Juha Kere, Stockholm)

09.45 - 10.30 Lecture: Neuronal regulation of CNS inflammation (Shohreh Issazadeh-Navikas, Lund)

10.30 - 11.00 Coffee break

11.00 - 11.45 Lecture: SKG mice as a model of rheumatoid arthritis (Shimon Sakaguchi, Kyoto)

11.45 - 12.30 Lecture: Murine models of asthma (Jan Lötvall, Göteborg)

12.30 - 14.30 Lunch combined with poster session

14.30 - 15.15 Lecture: Antibody induced arthritis (Kutty Selva Nandakumar, Lund)

15.15 - 15.45 Coffee break

15.45 - 16.30 Lecture: Primates as models for autoimmune disease (Bert T'Hart, Rijswijk)

16.30 - 17.30 Round table: How to use animal models for studies on human diseases? (All speakers)

Day 4

Genetic approaches on human inflammatory diseases part 2

Thursday, September 6^th
Lecture hall: Lundasalen, Regionhuset, Baravägen 1, Lund

08.50 - 09.00 Introduction: Åke Lernmark, Malmö

09.00 - 09.45 Review: Genes in complex autoimmune disorders (Åke Lernmark, Malmö)

09.45 - 10.30 Lecture: Genome wide association mapping in humans and dog (Kerstin Lindblad-Toh, Boston)

10.30 - 11.00 Coffee break

11.00 - 11.45 Lecture: The genetics of SLE: An update (Marta Alarcon-Riquelme, Uppsala)

11.45 - 12.30 Lecture: Modelling Multiple Sclerosis: Experimental Autoimmune Encephalomyelitis variants representing distinct aspects
                                 of human disease (Hartmut Wekerle, Martinsried)

12.30 - 14.30 Lunch combined with poster session

14.30 - 15.15 Lecture: Mouse models of SLE (Edward Wakeland, Dallas)

15.15 - 15.45 Coffee break

15.45 - 16.30 Lecture: MS genetics (Jan Hillert, Stockholm)

16.30 - 17.30 Round table: How to find human genes controlling chronic inflammation? (All speakers)

Day 5

Mimicking human diseases using genetic approaches on animals

Friday, September 7^th
Lecture hall: Lundasalen, Regionhuset, Baravägen 1, Lund

08.50 - 09.00 Introduction: Rikard Holmdahl, Lund

09.00 - 09.45 Review: The use of wild population of mice (Edward Wakeland, Dallas)

09.45 - 10.30 Lecture: Human driven selection of animals as assets for finding genes (Leif Andersson, Uppsala)

10.30 - 11.00 Coffee break

11.00 - 11.45 Lecture: The use of heterogeneous stocks and the mouse genomic consortium (Martina Johannesson , Oxford)

11.45 - 12.30 Lecture: Mouse genetics (Dan Holmberg, Umeå)

12.30 - 14.30 Lunch combined with poster session

14.30 - 15.15 Lecture: New humanized HLA class II transgenic mice mimic human inflammatory diseases (Chella David, Rochester)

15.15 - 15.45 Coffee break

15.45 - 16.30 Lecture: Mouse models and the genetics of diabetes: is there a genetic overlap between type 1 and type 2 diabetes? (Ed Leiter, Bar Harbor)

16.30 - 17.30 Round table: Forward versus reverse genetics using animal models (All speakers)

Saturday, September 8^th Social Event, Excursion to Malmö (only for registered participants)

Day 6

Innate immunity

Sunday, September 9^th
Lecture hall: Fernströmsalen, BMC, Sölvegatan 19, Lund

08.50 - 09.00 Introduction: Catharina Svanborg, Lund

09.00 - 09.45 Review: Toll-like receptors and inflammatory diseases (Ralf Schumann, Berlin)

09.45 - 10.30 Lecture: Gamma/delta T cells at the interface of innate and adaptive immunity (Dieter Kabelitz, Kiel)

10.30 - 11.00 Coffee break

11.00 - 11.45 Lecture: Complement links to autoimmune disease (Leendert Trouw, Leiden)

11.45 - 12.30 Lecture: Selection on the human MHC poymorphism and importance to human infectious diseases (Ulf Gyllensten, Uppsala)

12.30 - 14.30 Lunch

14.30 - 15.15 Lecture: Antimicrobial peptides - key factors in innate immunity (Jens-Michael Schröder, Kiel)

15.15 - 15.45 Coffee break

15.45 - 16.30 Lecture: Innate immunity, host genetics and kidney infections (Catharina Svanborg, Lund)

16.30 - 17.30 Round table: Specificity versus recognition by innate immune players (All speakers)

Day 7

Adaptive immunity

Monday, September 10^th
Lecture hall: Lundasalen, Regionhuset, Baravägen 1, Lund

08.50 - 09.00 Introduction: Tomas Leanderson, Lund

09.00 - 09.45 Review: Imaging immune responses in real time in vivo (Paul Garside, Glasgow)

09.45 - 10.30 Lecture: Expression of tissue specific genes in the thymus and central tolerance (Georg Holländer, Basel)

10.30 - 11.00 Coffee break

11.00 - 11.45 Lecture: New genetic tools for molecular diagnosis of single molecules and cells (Mats Nilsson, Uppsala)

11.45 - 12.30 Lecture: Effector T cell differentiation and its physiological role in defence against pathogens and induction of autoimmunity
                                (Brigitta Stockinger, London)

12.30 - 14.30 Lunch combined with poster session

14.30 - 15.15 Lecture: Immunopathogenesis of celiac disease (Ludvig Sollid, Oslo)

15.15 - 15.45 Coffee break

15.45 - 16.30 Lecture: While B cells are spoiled, T cells do it everywhere: on vaccination, structure and evolution (Burkhardt Becher, Zurich)

16.30 - 17.30 Round table: Is tolerance and regulation dependent on self-antigen recognition? (All speakers)

Day 8

Inflammatory effector mechanisms

Tuesday, September 11^th
Lecture hall: Lundasalen, Regionhuset, Baravägen 1, Lund

08.50 - 09.00 Introduction: William Agace, Lund

09.00 - 09.45 Review: The function of the NADPH oxidase in the killing of microbes by neutrophils - to activate granule enzymes by inducing
                                ion fluxes rather than through free radical and HOCl generation! (Phillipe Behe, London)

09.45 - 10.30 Lecture: Molecular pathways of TNF receptor signaling (Stefan Schütze, Kiel)

10.30 - 11.00 Coffee break

11.00 - 11.45 Lecture: Regulation and effector functions of mast cells in the allergic inflammation (Silvia Bulfone-Paus, Borstel)

11.45 - 12.30 Lecture: The complex role of complement factors in the regulation of priming and effector inflammatory mechanisms (Anna Blom, Malmö)

12.30 - 14.30 Lunch combined with poster session

14.30 - 15.15 Lecture: Mechanism regulating T cell trafficking to peripheral tissues (William Agace, Lund)

15.15 - 15.45 Coffee break

15.45 - 16.45 Round table: Relations between inflammatory, destructive and healing mechanisms? (All speakers)

Day 9

Prediction and monitoring

Wednesday, September 12^th
Lecture hall: Lundasalen, Regionhuset, Baravägen 1, Lund

08.50 - 09.00 Introduction: Dick Heinegåf;rd, Lund

09.00 - 09.45 Review: Joint cartilage in disease development. Using molecular markers to examine the process, in diagnosis and as factors
                                influencing the process (Dick Heinegård, Lund)

09.45 - 10.30 Lecture: Autoimmunity to cartilage type II collagen in RA (Harald Burkhardt, Frankfurt)

10.30 - 11.00 Coffee break

11.00 - 11.45 Lecture: Prediction of subtypes of RA through expression analysis (Cor Verweij, Amsterdam)

11.45 - 12.30 Lecture: Immune responses predicting lupus (Marie Wahren-Herlenius, Stockholm)

12.30 - 14.30 Lunch combined with poster session

14.30 - 15.15 Lecture: Biomarkers for proinflammatory immunological memory (Hyun-Dong Chang, Berlin)

15.15 - 15.45 Coffee break

15.45 - 16.45 Round table: Can we predict onset and chronicity of inflammatory diseases? (All speakers)

16.45 - 17.00 Presentation of student prize winners, Scientific committee

17.00 - 17.15 Lecture: Prize winning student lecture 1, Student 1

17.15 - 17.30 Lecture: Prize winning student lecture 2, Student 2

17.30 - 17.45 Lecture: Prize winning student lecture 3, Student 3

19:30 Baltic Summer School Dinner (only for registered participants)

Day 10

New preventive and therapeutic treatment strategies and targets

Thursday, September 13^th
Lecture hall: Lundasalen, Regionhuset, Baravägen 1, Lund

08.50 - 09.00 Introduction: Johan Lund, Charnwood

09.00 - 09.45 Review: Cytokines and Inflammation-Tools for therapeutic intervention (Stefan Rose-John, Kiel)

09.45 - 10.30 Lecture: Immunomodulation with human recombinant autoantigens (Åke Lernmark, Malmö)

10.30 - 11.00 Coffee break

11.00 - 11.45 Lecture: Prospects for the use of NK-cells in immunotherapy against human cancer (Hans-Gustav Ljunggren, Stockholm)

11.45 - 12.30 Lecture: Oxidants for treatment of chronic arthritis (Malin Hultqvist, Lund)

12.30 - 14.00 Lunch

14.00 - 14.45 Lecture: Active anti-IgE immunotherapy for the treatment of allergy and asthma (Åsa Jansson, Uppsala)

14.45 - 15.15 Coffee break

15.15 - 16.00 Lecture: Estrogen receptor modulation for treatment of arthritis and inflammation triggered bone loss (Hans Carlsten, Göteborg)

16.00 - 17.00 Round Table: Can treatment be preventive or curative? (All speakers)

17.00 - 17.30 Concluding remarks and end of course (Scientific committee).